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64 00:07:41,196 --> 00:07:43,152 Çæ áæ ÓãÍÊí ....áã ÊÝÚáíä 65 00:08:00,517 --> 00:08:04,396 ÇáÍÞæ áæÑæäÒæ ØÇÍ ãä ÇáÞÇÑí æíäÒá Ïã 66 00:08:04,517 --> 00:08:07,236 Çææå íÇ ÍÈíÈí 67 00:08:07,357 --> 00:08:09,791 íÇáÇ åÐÇ ÇáÝÊì ÇáÔÌÇÚ 68 00:08:09,917 --> 00:08:11,873 áÇ ÊÎÇÝ ßá ÔíÁ ÊãÇã (( ãÇ íÔæÝ ÔÑ ÇäÔÇÁ Çááå )) 69 00:08:11,997 --> 00:08:14,557 ÑÇÍ Êßæä Çæßí 70 00:08:14,677 --> 00:08:16,554 ÇäÊæ ÚÇÑÝíä Çáíæã ãíáÇÏ ÇáãÓíÍ 71 00:08:16,677 --> 00:08:20,830 æßá Çáí ÈÇáãÏíäå íÌÑÈæä ÞæÇÑíåã ÇáÌÏíÏÉ 72 00:08:22,438 --> 00:08:26,192 íÇ ÈØá ÇäÇ ÚÊÞÏ Çäß áÇÒã ÊÞæá áÃäÓÈÃß Çáí ÕÇÑ ãÚÇß ÚáÔÇä íÓÊÇäÓæ 73 00:08:26,318 --> 00:08:29,355 ãÇÐÇ ÓæÝ íÝÚáæä ÇÐÇ Úáãæ Çäß ÊáÚÈ ÑÏ Óßíä 74 00:09:10,040 --> 00:09:15,398 ÇáÊÎØíØ ÇáÏãÇÛí ØÈíÚí æÇáÌãÌãå ÈÇáÇÔÚå ØÈíÚíÉ æÇáÝÍÕ ØÈíÚí 75 00:09:15,520 --> 00:09:18,910 ãæ ÚÇÑÝå ÔÞæá åÐÇ ÇáæáÏ Óáíã ÚÕÈíÇ 76 00:09:19,040 --> 00:09:21,918 íÇ ÏßÊæÑå ÍäÇ ãæÌæÏíä ÕÇÑáäÇ ËáÇË Óäíä ÈÃÝÑíÞíÇ 77 00:09:22,040 --> 00:09:24,508 ÈÌÒÑ ÇáÞãÑ ßãÇ äÚáã 78 00:09:24,640 --> 00:09:27,916 íãßä åæ ÍÇãá ãÑÖ ØÝíáí äÇÏÑ ¿¿¿ 79 00:09:28,720 --> 00:09:30,631 ßá ÔíÆ ÌÇÆÒ 80 00:09:39,441 --> 00:09:41,397 áæÑæäÒæ ãÇÐÇ ÊÝÚá 81 00:09:43,001 --> 00:09:44,957 áæÑæäÒæ !!!! 82 00:09:51,841 --> 00:09:55,629 åá ÊÓãÚäí íÇ ÍÈíÈí ¿¿¿¿ 83 00:09:55,761 --> 00:09:59,198 ÞÏ íßæä åÐÇ ÕÚæÈå Ýí ÇáÊÌåíÒ ÇáÓãÚí 84 00:09:59,322 --> 00:10:04,237 ÇáÇÐä ÊãÇã ãÇ ÝíåÇ ÔíÁ áÇßä ÇáãÎ íÚÇäí ãä ãÔÇßá ÇáÓãÚ 85 00:10:04,362 --> 00:10:08,275 ÞÕÏß Çäå Ýí Ôí íÃËÑ Úáì ãÎå ¿ 86 00:10:08,402 --> 00:10:11,838 íãßä ãÇÐÇ ¿¿¿ æÑã ¿ ÇáÊÕáí ÇáãÊÚÏÏ¿¿ 87 00:10:11,962 --> 00:10:13,998 íãßä Çä íßæä ÔíÁ ãä ÇáÏÑÒä 88 00:10:20,322 --> 00:10:21,835 WASHINGTON CHILDREN'S HOSPITAL 89 00:10:21,962 --> 00:10:23,919 Easter Weekend 1984 90 00:10:24,243 --> 00:10:28,759 ÇÓãÚ íÇ ÕÏíÞí ÇÑíÏß Çä ÊäÇã Ýí ÇáãÓÊÔÝì áãÏÉ ËáÇËÉ ÇíÇã 91 00:10:28,883 --> 00:10:30,714 íÓÊØíÚ Çåáß ÈÇáÞÏæã 92 00:10:30,843 --> 00:10:33,755 áÇÒã ÇäÓæí ÝÍæÕÇÊ ááÍÕæá Úáì ÇáÍá 93 00:10:40,083 --> 00:10:42,074 ÊÓãÚ ÇáÕæÊ ¿ 94 00:10:42,523 --> 00:10:46,277 Îáí ÇÚíæäß Úáì ÇáäÞØå ÚáÔÇäí æåÐÇ ÑÇÍ íÓÇÚÏäí 95 00:10:47,603 --> 00:10:49,435 ÇæßíÛãÖ ÇÚíæäß 96 00:11:02,564 --> 00:11:05,920 Îáí ÇÚíæäß ãÓßÑå Îáíß ØÈíÚí æÇËÈÊ 97 00:12:48,408 --> 00:12:52,765 ÈØÈíÚÉ ÇáÍÇá ãåÑÌÇä ÚíÏ ÇáÝÕÍ ßÇäÊ ãæÌæÏå ÞÈá ÞÈá æÞÊ Øæíá ãä íÓæÚ ÇáØÝá 98 00:12:52,888 --> 00:12:55,881 Ýí ÇáÇæÞÇÊ ÇáæËäíÉ æåí ÚáÇãÇÊ ÈÏÇíÇÊ ÇáÑÈíÚ 99 00:12:56,009 --> 00:12:59,774 ÇáÈíÖå ÊÎÈÑäÇ ÈÃä ÇáÇÑÖ ÓæÝ ÊæáÏ ãä ÌÏíÏ 100 00:12:59,775 --> 00:13:00,958 ÊãÇã ãËá ÝÑÎ ÇáØÝá ÇáÕÛíÑ 101 00:13:01,089 --> 00:13:03,728 äÚã áÞÏ ÝåãÊ ÓíÏå ÇÏæä 102 00:13:04,129 --> 00:13:06,199 ÏßÊæÑ ÌíÏÇáæä ÌÇåÒ ÇáÇä 103 00:13:06,329 --> 00:13:09,878 áæÑæäÒæ ÑæÍ ØÚãí ÇáÓãß 104 00:13:10,529 --> 00:13:12,565 íáÇ íÇ ÍÈíÈí ÇÊÓ Çæßí 105 00:13:12,689 --> 00:13:16,523 ÑÇÍ äÑÌÚ ÈÓ ÚØäì æÞÊ Çæßí 106 00:13:16,649 --> 00:13:18,605 ãä åäÇ 107 00:13:24,570 --> 00:13:26,526 ÇÌáÓí 108 00:13:39,370 --> 00:13:42,521 ãæ ãÍÊÇÌíä ßá åá ÇÒÚÇÌ 109 00:13:50,571 --> 00:13:51,481 áÐÇ 110 00:13:51,931 --> 00:13:55,287 ÇÑÌæß ÏßÊæÑ ãä Ïæä ãÊÇåÇÊ 111 00:13:58,411 --> 00:14:01,767 åäÇß ÇãÑÇÖ ÚÇÆáíå æåí ÍÇáå äÇÏÑå ÌÏÇ 112 00:14:01,891 --> 00:14:04,166 The leukodystrophies. 113 00:14:04,291 --> 00:14:07,442 áæÑæäÒæ ÚäÏå à á Ï 114 00:14:09,171 --> 00:14:14,087 ÇáÊÚííäÇÊ ãÍÏÏÉ ÇáãÏå åæ ÎØà æÑÇËí Ýí ÇáÇíÖ æíÄÏí Åáì ÊÏåæ ÇáãÎ 115 00:14:15,332 --> 00:14:19,769 Çäå íÄËÑ ÝÞØ Úáì ÇáÐßæÑ ¡ æÚÇÏÉ ÇáÐíä ÊÊÑÇæÍ ÇÚãÇÑåã Èíä 5 æ 10 ÓäæÇÊ 116 00:14:20,612 --> 00:14:24,571 ÇáÊÞÏã ÇáãÑÍáí ãäå áÇ åæÇÏå Ýíå æäåÇíÉ ÇãÑ áÇ ãÝÑ ãäå 117 00:14:25,732 --> 00:14:30,089 ßáÇ ÇáÇØÝÇá íãæÊæä ãä åá ãÑÖ Ýí ÛÖæä ÓäÊíä ãä ÇáÊÔÎíÕ 118 00:14:39,493 --> 00:14:41,643 æáíÓ åäÇß Çí ÇÓÊËäÇÁÇÊ 119 00:14:42,773 --> 00:14:44,729 ÇäÇ ÇÓÝ 120 00:14:46,813 --> 00:14:49,168 åá ÇäÊ ãÊÃßÏ äÚã 121 00:14:51,333 --> 00:14:53,528 áæÑæäÒæ íÙåÑ ÚáÇãÇÊ äåÇÆíå 122 00:14:53,653 --> 00:14:59,603 áÏíå ãÓÊæì ÚÇáí ãä ÇáÏåæä ÈÔßá ÛíÑ ØÈíÚí Ýí Ïãå 123 00:15:02,374 --> 00:15:04,126 Ãæå ! 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00:48:33,531 ÍÓäÇ, äÍä äÞÏÑ Ðáß áÐÇ ÞãäÇ ÈÅÚÏÇÏ ãíÒÇäíÉ 539 00:48:33,653 --> 00:48:35,962 Úáì ÇÓÇÓ ÇÑÈÚíä ãÔÇÑßÇ áãÏÉ íæãíä 540 00:48:36,093 --> 00:48:40,292 äÍä äÚÊÞÏ ÈÃäå íãßä ÇáÞíÇã Èå È 35¡000 $ æÇäÇ æÒæÌÊí ÓæÝ äÒíÏ ÇáãÈáÛ 541 00:48:40,414 --> 00:48:43,611 áÇ íãßä Çä äØáÈ ãäß ÊÍãá ÇáÊßáÝÉ Çæå áÇ áÇ áÇ 542 00:48:43,734 --> 00:48:46,248 åÐÇ ÇÞá ãÇ äÝßÑ Èå 543 00:48:46,374 --> 00:48:49,446 æÈØÈíÚÉ ÇáÍÇá ÇáãÚåÏ ÇáÎÇÕ áä íßæä ÈÎØÑ 544 00:48:49,574 --> 00:48:54,125 áÇä ÚÇÆáÉ ÇáÇæÏä ÓæÝ íÊÍãáæä Çí äÝÕ 545 00:48:55,374 --> 00:48:59,049 æáÞÏ ÇÊÎÐäÇ ÇáÍÑíÉ Ýí ÞÇÆãÉ ÇáÏÚÇæí 546 00:48:59,174 --> 00:49:02,610 ÓÇãÍäí ÏßÊæÑ äíßæáÓ äÑíÏß Çä ÊÍÞÞ ÔÑØíä ¿ 547 00:49:02,734 --> 00:49:06,887 äæÏ ÇáäÏæÉ Çä ÊÃßÏ ÇáäÏæÉ ÇáÚáÇÌ 548 00:49:07,015 --> 00:49:11,964 æãíßá æÇäÇ äÑíÏ Çä äÔÇÑß Ýí ÇáãäÇÞÔÉ 549 00:49:21,175 --> 00:49:25,054 ãÇÑËÇ ÇÎÔì Çä ÚáíäÇ Çä äÖíÝ ÚÈÁ Úáì Úãáßí 550 00:49:25,175 --> 00:49:27,894 æáßäå Ýí ÓÈÈ æÌíå ÌÏÇ 551 00:49:28,015 --> 00:49:32,089 áÞÏ ÞÑÑäÇ ÚÞÏ ÇáäÏæÉ ÇáÇæáì Úä ÇáÊÚííäÇÊ 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ÓæÝ ÇÈÞì ÍÊì........ 861 01:11:43,418 --> 01:11:46,138 áÇ¡ íÌÈ Çä ÊäÊåí ÇááíáÉ ãíßíá ÇåÏÆí !! 862 01:11:46,259 --> 01:11:49,968 æßÇáÊß ÓæÝ ÊÊáÞáì ÇáÔíß Èíæã ÇáÛÏ 863 01:11:50,099 --> 01:11:53,535 ÇäÙÑí ÑæË äÍä ÌãíÚÇ ãÏãäíä ãÎÏÑÇÊ ÞáíáÇ åäÇ 864 01:11:53,659 --> 01:11:58,130 ÇäåÇ ÊÊÍÏË Úä ÇáÊäÓíÈ íÇ ÏíÏÑí æåí ßäÇíÉ Úä ÏÇÑ ÇáÚÌÒÉ 865 01:11:58,259 --> 01:12:02,252 áÑæäÒæ áÏíå ãÇ íßÝí áßí íÊÍãá æäÍä áÇ äÑíÏ Çä äÚÑÖ ÇäÝÓäÇ áÔß æÇáíÃÓ 866 01:12:02,379 --> 01:12:04,973 ÇäåÇ ãÑåÞÉ åÐÇ ßá ãÇ Ýí ÇáÇãÑ 867 01:12:05,099 --> 01:12:09,092 áÇ ÇÚÑÝ íÌÈ Çä äÞæá ÈÚÖ ÇáÔíÁ 868 01:12:09,219 --> 01:12:11,176 ÎÙÇ ÓÚíÏÇ 869 01:12:20,220 --> 01:12:22,211 ãÇ ÑÓ 1985 870 01:13:04,182 --> 01:13:06,457 ãÓÇÁ ÌíÏ "ÇæÏíäí"ø 871 01:13:06,582 --> 01:13:08,698 ÇäÙÑ ãÇÐÇ æÌÏÊ 872 01:13:08,822 --> 01:13:11,256 ÇäÙÑ Çáì åÐÇ 873 01:13:13,142 --> 01:13:15,098 ÏÚäí ÇÑíß 874 01:13:16,022 --> 01:13:18,138 Çíä äÍä ¿ åäÇ 875 01:13:22,182 --> 01:13:25,619 ßÇä Ðáß ãä íæäíæ 83 ÞÈá 21 ÔåÑÇ ÝÞØ 876 01:13:32,343 --> 01:13:36,734 ÊÚáãæä áÞÏ ÍÇä ÇáæÞÊ íÇ ÑÝÇÞ ÈÃä ÊåÏÃæä ÇäÝÓßã 877 01:13:36,863 --> 01:13:38,819 ÏíÏÑí 878 01:13:40,143 --> 01:13:43,294 ÇÐÇ ßäÇ äÚÑÝ ÈÃäåÇ ÓæÝ ÊäÌÍ Ýí äÕÝ ÇáØÑíÞ 879 01:13:45,063 --> 01:13:48,260 ÝÈÐáß äÍä äÚÑÝ ãÇÐÇ äÝÚá ÈÚÏ Ðáß 880 01:13:48,383 --> 01:13:52,616 ÇÞæÓÊæ ßã ÚÏÏ ÇáãÑÇÊ ÇáÊí ÑÃíÊß ÈåÇ äÇÆã .... 881 01:13:52,744 --> 01:13:56,134 ÊÍÊ ßæãÉ ãä ÇáÇæÑÇÞ ÇáÈÍËíÉ ãÚ ÇáÇÖæÇÁ ÇáãÖÇÆÉ 882 01:13:56,264 --> 01:13:59,574 æãä Ëã ÊÕÍæÇ æÊÓÍÈ äÝÓß Çáì ÇáãßÊÈ 883 01:13:59,704 --> 01:14:01,581 Çáì ãÊì ÓæÝ ÊÓÊãÑ ßÐáß 884 01:14:01,704 --> 01:14:04,821 ÇÐÇ ãÑÖÊ - åá ÊÓÊØíÚ...¿ ãÇÐÇ ÓæÝ ÊÝÚá ãä ÇÌá ÇáãÇá 885 01:14:04,944 --> 01:14:08,414 ãÇÐÇ ÊÞÕÏíä ÈÍÞ ÇáÅáå......... Çäå ÇÈäí 886 01:14:08,544 --> 01:14:14,301 äÚã¡ æäÝÓ ÇáÔíÁ ßÑÓÊíäÇ æÝÑÇäÓßæ ! áã ÊÑÇåã ãäÐ ÓäÉ ÍÊì ÇáÇä 887 01:14:14,424 --> 01:14:16,381 ÇÓãÚäí 888 01:14:18,585 --> 01:14:21,941 íÌÈ Çä Êßæä åäÇß ÍíÇÉ æÑÇÁ áæÑæäÒæ 889 01:14:23,065 --> 01:14:26,102 ãÇÐÇ ÊÞÕÏíä ! åá ÊÑíÏíä ãäí Çä ÇÓÊÓáã ¿ 890 01:14:26,225 --> 01:14:29,774 Çæå, íÇÑÌá äÍä äÚÑÝ ÍÊì áæ ÍÇæáÊ ÝÞÏ ÌÚáÊ ãÓÊæÇå ãä ÇáÇÓÝá Çáì ÇáæÖÚ ÇáØÈíÚí 891 01:14:29,905 --> 01:14:31,896 áÇ íãßä áÏãÇÛå ÇÕáÇÍ äÝÓå ! 892 01:14:32,025 --> 01:14:35,540 ßã ãÇíáíä ÈÞí áå ¿ åá ÓÃáÊ äÝÓß Ðáß ãä ÞÈá ¿ 893 01:14:35,665 --> 01:14:39,863 ÏíÏÑí¡ ÇáÇä åÐÇ íßÝí ¿ áÇ áÇ ÊÓÊÚÈØ ¿ 894 01:14:39,985 --> 01:14:43,342 ÇäÇ ÇÚáã ÈÃäß ÊÚáã æáÇßäåÇ áÇ ÊÚáã 895 01:14:44,786 --> 01:14:46,742 áíÓ ãä Çí æÞÊ ãÖì ¿ 896 01:14:47,906 --> 01:14:52,422 íÌÈ Çä ÊÓÇÚÏäí ãÚåÇ æåí áÇ ÊÑíÏ Çä ÊäÇã æáÇ Çä ÊÃßá 897 01:14:53,466 --> 01:14:56,424 ÇäÇ ÎÇÆÝÉ ÚáíåÇ ÇÚÊÞÏ ÈÃäåÇ ÊÎÓÑ äÝÓåÇ 898 01:14:58,026 --> 01:15:02,065 åá ÊÑì ßíÝ åí ãÚå ¿ áÇ ÊÓÊØíÚ Çä ÊÊÑßå 899 01:15:02,186 --> 01:15:04,142 ãÓßíäÉ íÇ ÏíÏÑí ¿ 900 01:15:04,866 --> 01:15:08,177 ÊÊÍÏËíä ßÃäßí ÇáãÑÃÉ ÇáæÍíÏÉ ÇáÊí áã íÓÈÞ áåÇ Çä íßæä áåÇ æáÏ íÓÊØíÚ ÇáÊÍÏË 901 01:15:08,307 --> 01:15:11,140 ãíßíá ÏíÏÑí ßÇäÊ ÊÊÍÏË ÈÍÈ 902 01:15:11,267 --> 01:15:13,622 ÇäÇ ÝÞØ ÇÞæá áßí ãÇ ÇÑì 903 01:15:13,747 --> 01:15:17,581 ãä ÇÌáßã íÌÈ Çä íßæä ÍíÇÉ ááÑæäÒæ 904 01:15:17,707 --> 01:15:20,112 åá ÊÚÊÞÏíä ÈÇäå áíÓ áå ÕæÊ 905 01:15:20,113 --> 01:15:23,225 ÈÃäå áä íÚíÔ æåæ íÃßÏ áäÇ¿¿ 906 01:15:23,347 --> 01:15:25,861 ÇÐÇ áã ÊÓÊØíÚíä ÑÃíÊ Ðáß áÇ íæÌÏ ãßÇä áßí åäÇ 907 01:15:25,987 --> 01:15:29,138 ãíßíá ÈÍÞ Çááå áÇíæÌÏ áßí ãßÇä åäÇ ÇäåÇ ÇÎÊßí ¿ 908 01:15:29,267 --> 01:15:33,978 ÇäÇ ÇÚÊÞÏ ÈÃäßí ÊÝÞÏíä äÝÓßí ãíßíá ÍÓäÇ ÇäÇ íÌÈ Çä ÊÐåÈíä 909 01:15:35,268 --> 01:15:38,305 ÇæÛÓÊæÇ ÓÇÚÏåÇ áÊæÙÈ ÍÞÇÆÈåÇ ÇäÇ ÐÇåÈÉ áÃÈääÇ 910 01:15:38,428 --> 01:15:42,387 ÇÎÊß Úáì ÍÞ ÇäÊí ãÌäæäÉ ÍÞÇ ãÌäæäÉ 911 01:15:42,508 --> 01:15:44,863 åá ÊÚÊÞÏ ÈÃäí ÛÈíÉ áÊßáãí Úä ÇÈääÇ 912 01:15:44,988 --> 01:15:47,456 äÚã ! äÚã! ãÌäæäÉ 913 01:15:47,588 --> 01:15:51,297 ãÌäæäå ! ãÌäæäÉ ÑÃÓß ãáæË 914 01:15:51,908 --> 01:15:57,461 ÝÞØ ÇáÇãÑÃÉ ÇáãÌäæäÉ ÇáÊí ÊÊÌäÈ ßäíÓÊåÇ æÒæÌåÇ æÚÇÆáÊåÇ 915 01:15:57,589 --> 01:16:00,786 ÇäÇ ÌÏÇ ÇÓÝÉ áã Çßä ÇÑíÏ ÈÐáß Çä íÍÕá 916 01:16:00,909 --> 01:16:06,222 ßíÝ áí ÈÃä ÇÓÊãÊÚ ÈÔíÁ æåæ áÇ íÓÊãÊÚ ÈÃí ÔíÁ 917 01:16:06,349 --> 01:16:10,058 ßíÝ áß ÈÃä Êßáãäí Úä ÍÈå ¿ æÇäÊ Êåæä Úáíå ßá ÔíÁ 918 01:16:10,189 --> 01:16:13,704 ÇäÊ Êáæãíä ÇáÌãíÚ Êßáãí Úä äÝÓßí æÚä Ïãß ÇáãÊÓãã 919 01:16:13,829 --> 01:16:15,785 áÇ áÇ 920 01:16:34,630 --> 01:16:36,905 ÓíÏÉ ÇæÏæäí!!!!!!!!!!1 ÅÌáÈí ÇáÇäÈæÈ 921 01:16:37,030 --> 01:16:38,622 åá ÚäÏßí ÇáÇäÈæÈ 922 01:16:38,750 --> 01:16:41,469 áÇ ÊåÒíä ÈÑÃÓßí Þæáí äÚã ÊÑßíÒí ãÚ áæÑæäÒæ 923 01:16:41,590 --> 01:16:44,900 ÚÒíÒí ÇäÙÑ Çáí ÇÓãÚ ÕæÊ ãÇãÇ ÎáíäÇ äÚÏ 924 01:16:45,030 --> 01:16:47,784 æÇÍÏ ÇËäíä ËáÇËÉ ÇÑÈÚÉ 925 01:17:05,071 --> 01:17:09,030 ÇäÇ ÇÓßäå Èßá ãÇ ÇÓÊØíÚ Çä ÇÝÚá áÓÊ ÇÚáã ãÇÐÇ ÇÝÚá ÇíÖÇ 926 01:17:19,192 --> 01:17:23,151 ßíÝ íãßäå Çä íÊÍãá Ðáß áÓÇÚÇÊ ØæíáÉ 927 01:17:25,592 --> 01:17:27,548 ÇÛæÓÊæ 928 01:17:28,472 --> 01:17:32,226 ÇÚÊÞÏ ÈÃäå áä íÓÊØíÚ Çä íÊÍãá Ðáß áÓÇÚÇÊ ÇßËÑ 929 01:18:03,314 --> 01:18:06,545 ãíßíá ÏÚíäí ÃÎÐå 930 01:18:06,674 --> 01:18:08,949 íÌÈ Çä ÊÑÊÇÍí Çä ÌíÏÉ 931 01:18:09,714 --> 01:18:12,069 ÕÈ ÇÞåæå 932 01:18:20,874 --> 01:18:23,308 áæÑæäÒæ áæÑæäÒæ ÇÓãÚ áãÇãÇ 933 01:18:24,234 --> 01:18:26,270 åá ÊÓÊØíÚ ÓãÇÚí íÇ ÚÒíÒí 934 01:18:26,394 --> 01:18:28,989 ÇÐÇ ßÇä åÐÇ ÕÚÈ Úáíß íÇ ÍÈíÈ ÞáÈí 935 01:18:29,115 --> 01:18:33,586 ÍÇæá Çä ÊØíÑ .....ØíÑ Èßá ÓÑÚÊß Çáì ÇáãÓíÍ ÇáÕÛíÑ 936 01:18:36,355 --> 01:18:38,311 Çæßí ¿ 937 01:18:40,195 --> 01:18:42,345 ãÇãÇ æÈÇÈÇ ÓæÝ íßæäæä ÈÃÝÖá ÍÇá 938 01:19:20,037 --> 01:19:23,586 áã ÇÑì ÔíÁ äÇÏÑ ßåÐÇ ßåÐÇ ÇáæáÏ ãËÇÈÑÉ 939 01:19:28,277 --> 01:19:30,666 íæÌÏ ÓÑíÑ ãÊÇÍ Ýí ÇáØÇÈÞ ÇáÇÚáì 940 01:19:30,797 --> 01:19:33,152 áÇ áÇ áÇ Ýí ÏÇÑ ÇáÚÌÒÉ áÇ 941 01:19:34,037 --> 01:19:35,914 ÓæÝ íßæä ÓåáÇ Úáì ÇáÌãíÚ 942 01:19:36,037 --> 01:19:38,790 æáä íßæä Ðáß ÔÑÝ ááÑæäÒæ 943 01:19:56,798 --> 01:19:58,834 ãíßíá ÊÚÇáí 944 01:19:58,958 --> 01:20:01,347 ãÇÐÇ ÊÚÇáí åíÇ 945 01:20:01,478 --> 01:20:03,434 ããÑÖÉ äÚã 946 01:20:12,919 --> 01:20:16,673 æÇáÇä Çáíæã ÓæÝ äÃßá ãæÞÇí áÞãÉ ãáíÆÉ ÇáÝã 947 01:20:16,799 --> 01:20:18,915 ÇäÇ áÓÊ ÌÇÆÚÉ áÇ áÇ áÇ ÇäÊ Çßá 948 01:20:19,039 --> 01:20:20,028 ÇÌáÓí 949 01:20:20,159 --> 01:20:23,151 ãíßíá ÇÌáÓí 950 01:20:23,279 --> 01:20:27,511 ãä ÈßÑÇ ÇáÕÈÍ Çá ÇæÏíä íÍÊÇÌæä ØÇÞÊåã 951 01:20:27,639 --> 01:20:31,996 æÇáÇä ÇÓãÚí áÞÏ ÔÑÚäÇ ÈÇä íßæä Ïã ÑæáæäÒæ ØÈíÚí ÕÍíÍ 952 01:20:32,119 --> 01:20:37,877 æÈÒíÊ ÇáÇæáíß ÝÚáäÇ ÇáäÕÝ æßÇä Ðáß ÈÇáÍÙ 953 01:20:38,000 --> 01:20:42,755 æßÇä ÇßËÑ ÈÏáÇ ãä ÇáÍÙ áÇ ßÇä ÇáÍÙ ÇáãáÇÍÙÉ ÝÞØ 954 01:20:42,880 --> 01:20:45,758 ÑíÒæ áÇÍÙ ÔíÁ Ýí ÇäÈæÈ ÇáÇÎÊÈÇÑ ÇáíÓ ßÐáß 955 01:20:45,880 --> 01:20:47,950 áÞÏ ÌÑÈäÇåÇ Úáì áæÑæäÒæ 956 01:20:48,080 --> 01:20:51,356 æáÇÍÙ ÑíÒæ ÇäÎÝÇÖ 50 ÈÇáãÇÆÉ Ýí ÇáÎáÇíÇ ÇááíÝíÉ 957 01:20:51,480 --> 01:20:54,438 æáÇÍÙäÇ ÇäÎÝÇÖ 50 Ýí ÇáãÆÉ Ýí áæÑæäÒæ 958 01:20:55,800 --> 01:20:59,874 ãíßíá åÐÇ åæ ÇáÍÙ åÐå åí ÇáãáÇÍÙÉ 959 01:21:00,001 --> 01:21:04,119 åÐÇ ßá ãÇ Ýí ÇáÇãÑ áíÓ ãÝåæã 960 01:21:04,241 --> 01:21:07,551 áÍÊì äÚáã áãÇÐÇ äÌÍÊ ÝÞØ Ýí ãäÊÕÝ ÇáØÑíÞ 961 01:21:07,681 --> 01:21:11,469 ßíÝ íãßääÇ Çä äÊæÞÚ ÇáäÌÇÍ ØæÇá åÐÇ ÇáØÑíÞ 962 01:21:11,601 --> 01:21:15,958 ÇÑíÏ Çä ÇÝåã íÇ ãíßíá íÌÈ Çä ÊÝåãí 963 01:21:16,961 --> 01:21:19,953 áÐáß ãä ÇáÛÏ íÌÈ Çä äÐåÈ Çáì ÇáãßÊÈÉ 964 01:21:20,681 --> 01:21:25,517 áÇ áÇ áÇ äÓÊÚÑÖ ßá ãÇ ßÊÈ ßáÔíÁÚáì ÇÓÊÞáÇÈ ÍãÖ ÇáÏåäíÇÊ 965 01:21:25,642 --> 01:21:28,076 ßá ßáãÉ äÔÑÊ Ýí ÇáÚÞÏ ÇáãÇÖí 966 01:21:28,202 --> 01:21:31,532 áÐÇ ßáí íÌÈ Çä ÊÃßáí 967 01:21:30,562 --> 01:21:33,759 ãåãÇ ßÇäÊ ØÇÞÊí Çæ ßã ÊÈÞí ãä æÞÊí ßá ãÇ ÇÑíÏå Çä ÇÞÖíå ãÚ áæÑæäÒæ 968 01:21:33,882 --> 01:21:36,476 ÇäÊí áä ÊÊÑßíå ÇäÇ ÓæÝ ÇÐåÈ Çáì ÇáãßÊÈÉ 969 01:21:36,602 --> 01:21:38,877 ÓæÝ ÇÚãá äÓÎ áßí æÇÌáÈåã áßí Ýí ÇáÈíÊ 970 01:21:39,002 --> 01:21:42,597 ÇÛæÓÊæÇ äÍä ÊÍÊ ÇáÑåä ÇáÚÞÇÑí ÇáËÇäí ÇäÊ áä ÊÓÊØíÚ ÇáÐåÇÈ Çáì ÇáÚãá 971 01:21:42,722 --> 01:21:46,078 ãíßíá ÓæÝ ÇÚãá ÓæÝ ÊäÓÇÈ ÈØÑíÞÉ Çæ ÈÃÎÑì 972 01:21:47,322 --> 01:21:51,077 ãíßíá åÐÇ ãåã ÇäÇ ÇÍÊÇÌßí 973 01:21:53,603 --> 01:21:55,559 ÇÍÊÌßí íÇ ãíßíá 974 01:21:57,203 --> 01:21:58,875 áÐÇ ßáí 975 01:22:17,244 --> 01:22:20,475 ÑÇÆÚ 976 01:22:20,724 --> 01:22:23,682 April 1985 ÈÚÏ 12 ÔåÑ ãä ÇáÊÔÎíÕ 977 01:22:41,685 --> 01:22:43,641 ÈÊí ÈÊí 978 01:22:44,565 --> 01:22:48,638 All these fatty-acid studies concentrate on the middle of the chain... 979 01:22:48,765 --> 01:22:52,440 because the medium-chain saturates are implicated in cholesterol. 980 01:22:52,565 --> 01:22:55,955 So what do these researchers do? Think cholesterol, cholesterol. 981 01:22:56,085 --> 01:22:59,077 C12. C14, C-bloody-16! 982 01:22:59,205 --> 01:23:02,402 Augusto, what are you looking for? -I am looking... 983 01:23:02,525 --> 01:23:06,678 for the long end of fatty-acid chains! -All right. Write it down for me. 984 01:23:06,806 --> 01:23:09,843 These researchers should be doing something about this. 985 01:23:09,966 --> 01:23:12,196 Write it down. -Long-chain fatty acids. 986 01:23:12,326 --> 01:23:15,921 C18 through C26. 987 01:23:16,566 --> 01:23:18,284 Saturated. 988 01:23:18,406 --> 01:23:20,715 Monounsaturated, OK? 989 01:23:20,846 --> 01:23:23,838 OK. Now I want you to go off to lunch. 990 01:23:23,966 --> 01:23:27,925 Have yourself a good lunch and I'm gonna see what I can do. 991 01:23:38,087 --> 01:23:40,282 This is the best I could do at short notice. 992 01:23:40,407 --> 01:23:43,843 One article from a veterinary science journal about pigs. 993 01:23:43,967 --> 01:23:48,040 But it's on your long-chain fats. -Well, thank you, Betty. 994 01:23:48,167 --> 01:23:51,045 Listen, I am very sorry about... 995 01:23:51,167 --> 01:23:53,920 Oh, well, you're Italian. 996 01:23:57,768 --> 01:24:02,125 72, 73, 74... 997 01:24:02,248 --> 01:24:06,287 That's it. 75, 76,... 998 01:24:07,128 --> 01:24:10,359 77, 78... 999 01:24:10,888 --> 01:24:13,038 Nice going, Mrs Odone. 1000 01:24:14,088 --> 01:24:17,967 That's it, my love. You know only the strongest, bravest boy,... 1001 01:24:18,088 --> 01:24:21,684 only a very special person like you is chosen to fight the boo-boo. 1002 01:24:21,809 --> 01:24:24,277 I'll give him a little water, OK? 20cc's? 1003 01:24:24,409 --> 01:24:25,444 Yes. 1004 01:24:25,569 --> 01:24:30,484 And, Nancy Jo, why don't you tell Lorenzo what an excellent job he did? 1005 01:24:30,609 --> 01:24:32,884 An excellent job you did, Lorenzo. 1006 01:24:33,009 --> 01:24:38,163 Sometimes I wonder, my love, if people realise how incredible you truly are. 1007 01:24:40,689 --> 01:24:42,645 May 1985 1008 01:24:47,450 --> 01:24:49,884 Oh, thank you. Thank you very much. 1009 01:24:51,330 --> 01:24:53,605 Is this a new hobby or a nervous tic? 1010 01:24:56,210 --> 01:24:59,441 No, this is a simple mind at work, that's all. 1011 01:24:59,570 --> 01:25:03,768 See, each paperclip, Deirdre, is two carbon atom, right? 1012 01:25:03,890 --> 01:25:05,528 Oh, God! -No, no, no. 1013 01:25:05,650 --> 01:25:07,925 Really is two carbon atom, all right? 1014 01:25:08,050 --> 01:25:11,680 So we have C2, C4, C6, you know? 1015 01:25:11,811 --> 01:25:14,723 Now, here's what I try to do. I try to make a chain,... 1016 01:25:14,851 --> 01:25:18,605 a very long chain of monounsaturated fats. 1017 01:25:18,731 --> 01:25:22,201 This is the good guys, right? -OK, what are these? The bad guys? 1018 01:25:22,331 --> 01:25:24,765 Yes. These here... 1019 01:25:24,891 --> 01:25:27,405 is the bad guys, all right? 1020 01:25:27,531 --> 01:25:29,567 Now, Deirdre, what I'm trying to do... 1021 01:25:29,691 --> 01:25:32,000 I try to understand the relationship... 1022 01:25:32,131 --> 01:25:35,089 between the good guys and the bad guys. 1023 01:25:35,451 --> 01:25:38,250 So, OK, I am the enzyme, right? 1024 01:25:38,372 --> 01:25:43,571 And I reach out and grab a carbon atom and I put it on my chain, right? 1025 01:25:43,692 --> 01:25:45,125 Here is my chain. 1026 01:25:45,252 --> 01:25:47,891 Now, here, you be the bad-guy enzyme, OK? 1027 01:25:48,012 --> 01:25:51,607 No, no. Do this for me. You be bad-guy enzyme, all right? 1028 01:25:51,732 --> 01:25:53,165 Take this, all right? 1029 01:25:53,292 --> 01:25:58,286 Now you reach out and grab a carbon atom and put it on your bad-guy chain. 1030 01:25:58,412 --> 01:26:00,767 I had enough trouble with the kitchen sink. 1031 01:26:00,892 --> 01:26:05,489 No, no. You just do this and then I explain, OK? All right. 1032 01:26:05,613 --> 01:26:11,085 So let's each start now making our chains. 1033 01:26:11,213 --> 01:26:15,570 OK? All right? Do another one. That's good, Deirdre. 1034 01:26:15,693 --> 01:26:17,729 Good. We put another one on... 1035 01:26:17,853 --> 01:26:21,528 Here's the stuff on enzyme complexes. -Ah, thank you. Mille grazie. 1036 01:26:21,653 --> 01:26:23,484 Prego. -Prego! Very good. 1037 01:26:23,613 --> 01:26:25,968 Now, did you make the extra copies? -Oh, you bet. 1038 01:26:26,093 --> 01:26:28,449 Thank you very much. -For Michaela? How is she? 1039 01:26:28,574 --> 01:26:29,973 She's fine. 1040 01:26:30,094 --> 01:26:34,531 So here we are. We're making our chains more or less the same rate, right? 1041 01:26:34,654 --> 01:26:36,770 That's as one would expect, right? 1042 01:26:36,894 --> 01:26:40,045 But, now, Deirdre, if we were enzymes... 1043 01:26:40,174 --> 01:26:43,644 in the bodies of little rats and little pigs and Lorenzo,... 1044 01:26:43,774 --> 01:26:47,528 then the faster I go, the more you slow down. 1045 01:26:48,334 --> 01:26:50,609 Now, why would that be? 1046 01:26:50,734 --> 01:26:56,287 Why, the faster I go, would you slow down, if we are both separate enzymes? 1047 01:26:56,415 --> 01:27:01,091 It means that there has to be some kind of relationship going on. 1048 01:27:01,215 --> 01:27:05,447 We affect each other some way. There's some kind of interplay. 1049 01:27:05,575 --> 01:27:08,089 But what is it? 1050 01:27:08,215 --> 01:27:10,171 What is it? 1051 01:27:11,495 --> 01:27:13,247 May 29th 1985 1052 01:27:13,535 --> 01:27:15,491 One, two,... 1053 01:27:16,215 --> 01:27:18,525 three, four,... 1054 01:27:19,376 --> 01:27:21,970 five, six,... 1055 01:27:22,496 --> 01:27:24,088 seven candles. 1056 01:27:24,216 --> 01:27:26,935 And Mommy will blow them out for you. 1057 01:27:27,056 --> 01:27:29,012 Make a wish. 1058 01:28:07,858 --> 01:28:10,577 Michaela! They are the same enzyme! 1059 01:28:10,698 --> 01:28:15,613 There is one enzyme for both chains. It's the same bloody enzyme! 1060 01:28:15,738 --> 01:28:19,174 So if we keep the enzyme busy making monounsaturates... 1061 01:28:19,298 --> 01:28:21,766 It distracts it from elongating the saturates. 1062 01:28:21,898 --> 01:28:24,458 Right! So we have a way to trick nature. 1063 01:28:24,578 --> 01:28:27,570 Yes, it's a principle called "competitive inhibition". 1064 01:28:27,698 --> 01:28:30,815 So, Gus, do you think it's a reasonable hypothesis? 1065 01:28:30,938 --> 01:28:35,171 I think it's more. You've clarified the biochemical pathway. 1066 01:28:35,299 --> 01:28:37,972 Augusto, I really want to congratulate you. 1067 01:28:38,099 --> 01:28:42,331 This would explain why oleic acid is only partly successful. 1068 01:28:42,459 --> 01:28:46,134 Yes, it's C18, you see. It's too low down in the chain. 1069 01:28:46,259 --> 01:28:50,491 So we add a second barrier. We block the bad guys further up the chain,... 1070 01:28:50,619 --> 01:28:54,737 the saturates further up the chain, between C22 and C24. 1071 01:28:54,859 --> 01:28:57,009 There we stop the bloody things completely. 1072 01:28:57,139 --> 01:29:00,769 And how would you do that? -By adding monounsaturated C22. 1073 01:29:00,900 --> 01:29:03,573 That's erucic acid. -Yes, exactly. 1074 01:29:04,220 --> 01:29:06,211 Erm... 1075 01:29:06,340 --> 01:29:08,092 Martha? -Yes, Doctor? 1076 01:29:08,220 --> 01:29:13,248 Among our animal studies, you will find a file on erucic acid. 1077 01:29:13,380 --> 01:29:16,099 With an e... r-u-c-i-c. 1078 01:29:16,220 --> 01:29:18,176 OK. -Thank you. 1079 01:29:19,020 --> 01:29:21,534 You don't believe it will work? 1080 01:29:21,660 --> 01:29:26,815 I think what you have done is postulate a theory that could be of enormous benefit. 1081 01:29:26,941 --> 01:29:31,332 But, as for erucic acid, it creates cardiac problems in rats. 1082 01:29:32,101 --> 01:29:35,776 If it's not safe for rats, I don't know what justification there can be... 1083 01:29:35,901 --> 01:29:39,735 for using it as a therapy on humans. 1084 01:29:39,861 --> 01:29:41,613 But Gus, Gus,... 1085 01:29:41,741 --> 01:29:45,529 erucic acid is the chief component in rapeseed oil, right? 1086 01:29:45,661 --> 01:29:49,052 Rapeseed oil is a common food in China and India. 1087 01:29:49,182 --> 01:29:52,060 And their rate of heart disease is far lower than here. 1088 01:29:52,182 --> 01:29:55,811 All right, look at these documents. Cardiac lipidosis,... 1089 01:29:55,942 --> 01:30:00,060 myocardial lesions, cholesterol deposits in the adrenal gland... 1090 01:30:00,182 --> 01:30:03,060 and damage to the reproductive system. 1091 01:30:03,182 --> 01:30:06,777 I'm afraid the weight of evidence is much too great. 1092 01:30:06,902 --> 01:30:09,370 And no human-studies review committee... 1093 01:30:09,502 --> 01:30:13,575 will ever do anything but discard erucic acid out of hand. 1094 01:30:13,702 --> 01:30:17,935 But the human studies have been accomplished by history. 1095 01:30:18,063 --> 01:30:22,375 They have been eating the stuff in these countries for thousands of years. 1096 01:30:22,503 --> 01:30:26,257 You can't expect me to start a protocol based on that kind of assertion. 1097 01:30:26,383 --> 01:30:28,533 You should examine your protocol... 1098 01:30:28,663 --> 01:30:32,212 when children are dying and find a way to research these... 1099 01:30:32,343 --> 01:30:36,131 It's common sense. -We simply have a contradiction. 1100 01:30:36,263 --> 01:30:40,052 We seek more information. We do not dismiss erucic acid out of hand. 1101 01:30:40,184 --> 01:30:44,462 Michaela, if I ignore all this evidence... 1102 01:30:44,584 --> 01:30:48,259 and we embark on a therapy based on erucic acid... 1103 01:30:49,944 --> 01:30:52,822 Something goes wrong. What then? 1104 01:30:53,384 --> 01:30:57,741 Well, then I suppose the risk-reward ratio is too unattractive for you. 1105 01:30:58,384 --> 01:31:00,340 I beg your pardon? 1106 01:31:01,464 --> 01:31:04,821 The life of one boy is not enough reward for you... 1107 01:31:04,945 --> 01:31:09,973 to risk the reputation of the institution and the esteem of your peers. 1108 01:31:11,385 --> 01:31:13,126 That was uncalled for. 1109 01:31:14,327 --> 01:31:16,978 Your responsibility is merely towards your own child. 1110 01:31:17,105 --> 01:31:21,940 My responsibility is towards all the boys that suffer from this disease,... 1111 01:31:22,065 --> 01:31:24,135 now and in the future. 1112 01:31:25,145 --> 01:31:28,581 Of course I anguish for the suffering of your boy. 1113 01:31:29,385 --> 01:31:33,823 And of course I applaud you for the efforts you make on his behalf. 1114 01:31:34,666 --> 01:31:37,624 But I will have nothing to do with this oil. 1115 01:31:38,786 --> 01:31:43,701 We are not asking, Doctor, for your anguish or your applause. 1116 01:31:43,826 --> 01:31:46,784 We are asking merely for a little courage. 1117 01:31:51,746 --> 01:31:53,702 OK. All right. 1118 01:31:58,427 --> 01:32:03,899 No, whatever the doctors say, reason tells us it is a risk worth taking. 1119 01:32:04,027 --> 01:32:08,100 But, my friend, we need a sympathetic collaborator, hm? 1120 01:32:08,227 --> 01:32:11,583 If it was in my hands, I would do anything I could to help, Mr Odone. 1121 01:32:11,707 --> 01:32:13,663 I have a boy of my own. 1122 01:32:14,507 --> 01:32:16,418 But I don't like our chances. 1123 01:32:16,547 --> 01:32:21,258 You know, they said the same thing about the oleic acid, and here it was,... 1124 01:32:21,388 --> 01:32:24,983 sitting right on the shelf. -This is a whole other ball game. 1125 01:32:25,108 --> 01:32:29,067 Extracting the saturated C24 and 26 from rapeseed oil... 1126 01:32:29,188 --> 01:32:32,305 It's very tricky. It would take our best chemist at least a year. 1127 01:32:32,428 --> 01:32:37,866 And then you would never get it past the FDA. Erucic acid for human consumption? 1128 01:32:37,988 --> 01:32:42,027 I'm sorry, but no one in the country is gonna touch it. 1129 01:32:42,148 --> 01:32:45,380 Well, what about outside this country, hm? 1130 01:32:45,509 --> 01:32:47,545 Uh, I wouldn't know where to send you. 1131 01:32:47,669 --> 01:32:52,379 Oh, Mr Pellerman! We're agents for over a dozen foreign companies. 1132 01:32:52,509 --> 01:32:54,386 There must be one that could help. 1133 01:32:54,509 --> 01:32:57,660 Maybe all we need to do is look at the list of the foreign companies. 1134 01:32:57,789 --> 01:33:00,701 No, you and your wife have enough to do. 1135 01:33:00,829 --> 01:33:05,380 I'm sure Mr Pellerman would be happy to make the calls for you. 1136 01:33:09,309 --> 01:33:11,028 We'd have to be covered, legally. 1137 01:33:11,150 --> 01:33:15,382 If anything goes wrong, this company is not going to be held liable. 1138 01:33:15,510 --> 01:33:18,582 Oh, we would not hold you liable. No, no. 1139 01:33:18,710 --> 01:33:24,467 And this... It would be greatly appreciated if we could circulate this. 1140 01:33:28,950 --> 01:33:33,705 "The interplay of monounsaturated and saturated fatty acids: 1141 01:33:33,830 --> 01:33:36,868 therapeutic application in ALD." 1142 01:33:36,991 --> 01:33:38,470 Wow. -You wrote this? 1143 01:33:38,591 --> 01:33:42,106 Yes. We felt that if we were asking for help,... 1144 01:33:42,231 --> 01:33:45,428 our rationale needs to be very clear. 1145 01:33:45,551 --> 01:33:50,944 We've all read your paper. It's a beautiful piece of biochemistry. 1146 01:33:51,071 --> 01:33:54,188 Over a hundred companies all say "too difficult". 1147 01:33:54,311 --> 01:33:57,747 Well, my first impression was that it's bloody impossible. 1148 01:33:57,871 --> 01:34:01,547 But I've been doing difficult fractionations for 40 years... 1149 01:34:01,672 --> 01:34:05,267 and I'd like to have a stab at it. -How long do you think, Mr Suddaby? 1150 01:34:05,392 --> 01:34:09,101 I've only six months before I retire, so we'll see. 1151 01:34:09,232 --> 01:34:14,181 All right. Then I'll let you get on with it. Call me if you have any questions. 1152 01:34:14,312 --> 01:34:16,268 Righto. Bye, then. 1153 01:34:25,792 --> 01:34:27,749 CRODA CHEMICALS London 1154 01:34:27,873 --> 01:34:32,822 September 1985 Seventeen Months After Diagnosis 1155 01:34:37,713 --> 01:34:39,669 Who could this be? 1156 01:34:43,273 --> 01:34:45,503 Ah, your good friend Wendy... 1157 01:34:45,633 --> 01:34:49,308 with all sorts of lovely vegetables and fruits. 1158 01:34:49,993 --> 01:34:51,950 Hi, Michaela. -Look what you brought us! 1159 01:34:52,074 --> 01:34:53,905 Hi, Lorenzo. 1160 01:34:54,034 --> 01:34:55,945 Jake's not in school today? 1161 01:34:56,074 --> 01:34:58,030 He's not feeling so good. 1162 01:35:00,354 --> 01:35:04,586 I'm going for a walk with Mrs Gimble and we shall be back shortly. 1163 01:35:04,714 --> 01:35:07,990 I've given him his oxcarbazepine and 15ml of water. 1164 01:35:08,834 --> 01:35:12,668 Do you want me to do anything else? -I'm sure he would love a story. 1165 01:35:12,794 --> 01:35:15,149 Do you have a problem with this? 1166 01:35:17,435 --> 01:35:19,391 Fine. 1167 01:35:25,515 --> 01:35:29,144 He's had a couple of tantrums. -Oh, I'm sorry. 1168 01:35:29,275 --> 01:35:31,231 It's OK. 1169 01:35:32,075 --> 01:35:36,034 Dr Rizzo got him in the oleic acid trial. -That's good. 1170 01:35:41,195 --> 01:35:43,152 Hi, Jake. 1171 01:35:44,596 --> 01:35:47,633 Hi, sweetie. Thank you for my potatoes. 1172 01:35:49,916 --> 01:35:51,872 Say hello, son. 1173 01:35:54,556 --> 01:35:56,911 Hi, Mrs... 1174 01:35:57,036 --> 01:35:59,994 Odone. 1175 01:36:09,037 --> 01:36:11,995 He saw the way Jaybird went. 1176 01:36:12,837 --> 01:36:15,192 He knows what's in store for him. 1177 01:36:21,077 --> 01:36:23,796 "They forgot their hunger and followed the bird." 1178 01:36:23,917 --> 01:36:25,873 "They came to an opening in the forest." 1179 01:36:25,997 --> 01:36:30,195 "Before them was a little cottage, gleaming in the rays of the setting sun." 1180 01:36:30,317 --> 01:36:34,106 "'Look, Gretel' exclaimed Hansel. 'That cottage is made of gingerbread."' 1181 01:36:34,238 --> 01:36:37,469 "'It really is' replied Gretel, running up and tasting a bit... 1182 01:36:37,598 --> 01:36:39,475 that she had pulled from the wall." 1183 01:36:39,598 --> 01:36:42,032 "'And the roof is shingled with butterscotch."' 1184 01:36:42,158 --> 01:36:46,071 "'The windowsills are made of chocolate' declared Hansel, breaking off a bit." 1185 01:36:46,198 --> 01:36:49,668 "'The windowpanes are clear candy' said Gretel. At that moment" 1186 01:36:49,798 --> 01:36:53,268 Nancy Jo, do you think you could muster just a tad more enthusiasm? 1187 01:36:53,398 --> 01:36:56,231 Lorenzo loves words. He loves the sound of language. 1188 01:36:56,358 --> 01:36:59,635 Well, I'm paid to nurse, not read stories. 1189 01:37:00,479 --> 01:37:03,835 You've decided his mind doesn't need as much nurturing as his body? 1190 01:37:03,959 --> 01:37:05,915 What mind? 1191 01:37:06,479 --> 01:37:08,435 I beg your pardon! 1192 01:37:09,639 --> 01:37:11,914 Nothing. 1193 01:37:12,039 --> 01:37:14,030 Get out. 1194 01:37:14,159 --> 01:37:16,627 Look, Mrs Odone... -Just get out. 1195 01:37:16,759 --> 01:37:20,035 I've read up on this disease! I know what it's done to his brain! 1196 01:37:20,159 --> 01:37:23,755 Lorenzo doesn't need this from a subliterate with a double-digit IQ! 1197 01:37:23,880 --> 01:37:26,269 Face it. The lights are out and nobody's home! 1198 01:37:26,400 --> 01:37:28,789 Just get out. Go! -Well, merry Christmas. 1199 01:37:28,920 --> 01:37:31,070 Get out! -Happy holidays! 1200 01:37:31,880 --> 01:37:33,836 And a joyous yuletide! 1201 01:37:41,440 --> 01:37:43,829 "Near a great forest lived a poor woodcutter... 1202 01:37:43,960 --> 01:37:46,997 with his two children, Hansel and Gretel." 1203 01:37:47,120 --> 01:37:50,431 "Times were very hard and a day came when there was no food,... 1204 01:37:50,561 --> 01:37:52,597 except a little stale bread." 1205 01:37:52,721 --> 01:37:56,077 "But Hansel" was like you, my darling. 1206 01:37:57,321 --> 01:38:02,873 "He was a clever lad who knew how to solve difficult problems." 1207 01:38:04,561 --> 01:38:07,121 "The woodcutter was very sad" 1208 01:38:08,041 --> 01:38:10,555 Are you going to keep doing this? 1209 01:38:10,681 --> 01:38:14,721 She brought it on herself. She consigned herself to the outer darkness. 1210 01:38:14,842 --> 01:38:19,233 Michaela, Nancy Jo, she was a good nurse. You train her well. 1211 01:38:19,362 --> 01:38:22,240 Yes, but I want someone to give him more than medication. 1212 01:38:22,362 --> 01:38:25,798 Someone who will minister to his mind and his soul. 1213 01:38:26,722 --> 01:38:28,872 I think I've found him. -What? 1214 01:38:30,122 --> 01:38:33,194 I wrote to Omouri. I asked him to come and stay with us. 1215 01:38:33,322 --> 01:38:34,277 Omouri? -Yes. 1216 01:38:34,402 --> 01:38:38,362 Lorenzo is surrounded by women all day. I don't want him to grow up hag-ridden. 1217 01:38:38,483 --> 01:38:41,475 But you cannot take a boy out of his fishing village... 1218 01:38:41,603 --> 01:38:43,594 and bring him here to nurse Lorenzo. 1219 01:38:43,723 --> 01:38:47,272 Not to nurse him, to be his friend. To bring the Comoros into this room. 1220 01:38:47,403 --> 01:38:53,399 We cannot uproot this young man from his family, his way of life. 1221 01:38:54,443 --> 01:38:57,355 Where will he live? -Here, in Lorenzo's room. 1222 01:38:57,483 --> 01:39:00,441 But... he has no English. 1223 01:39:01,283 --> 01:39:04,196 He's a Muslim. An African. 1224 01:39:04,324 --> 01:39:09,557 We cannot bring an African to this racist country to be a second-class citizen. 1225 01:39:09,684 --> 01:39:12,517 This is Washington, DC. -He'll be part of this family. 1226 01:39:12,644 --> 01:39:15,363 I'll teach him English. There's a lot we can do for him. 1227 01:39:15,484 --> 01:39:17,440 Oh, Michaela... 1228 01:39:18,004 --> 01:39:19,960 Here. Sit down, sit down. 1229 01:39:21,524 --> 01:39:26,040 Now, the last time Omouri saw Lorenzo,... 1230 01:39:26,164 --> 01:39:28,120 he was climbing trees. 1231 01:39:28,244 --> 01:39:31,681 He was a wild and vibrant boy, full of life. 1232 01:39:35,125 --> 01:39:37,878 In the letter that you wrote to Omouri,... 1233 01:39:39,005 --> 01:39:43,760 did you tell him what he will see when he walks into this room? 1234 01:39:45,165 --> 01:39:50,000 I told him he'd see a young man who was very ill and had need of a friend. 1235 01:39:50,765 --> 01:39:52,323 That is all? 1236 01:39:52,445 --> 01:39:55,961 How would you have me describe him? As a biochemical conundrum? 1237 01:39:56,086 --> 01:39:58,042 Non è vero. 1238 01:39:58,886 --> 01:40:01,844 You know he is not that for me. 1239 01:40:03,406 --> 01:40:06,955 Augusto, when you look at him, what do you see? 1240 01:40:09,486 --> 01:40:11,841 Tell me the truth. 1241 01:40:24,007 --> 01:40:26,601 It's very difficult... 1242 01:40:26,727 --> 01:40:29,161 to know for sure... 1243 01:40:30,167 --> 01:40:34,126 what is left of our Lorenzo. 1244 01:40:35,247 --> 01:40:39,798 If a person cannot move,... 1245 01:40:40,407 --> 01:40:42,363 cannot see,... 1246 01:40:43,247 --> 01:40:45,204 cannot speak,... 1247 01:40:46,168 --> 01:40:50,923 how can we know what is in the soul? 1248 01:40:55,928 --> 01:40:57,884 He is my little boy. 1249 01:40:59,008 --> 01:41:01,442 And my only wish... 1250 01:41:02,848 --> 01:41:06,807 is to have him back as he was before. 1251 01:41:14,729 --> 01:41:18,085 March 1986 Twenty-three Months After Diagnosis 1252 01:41:41,970 --> 01:41:45,121 How do I tell the man to give up? -Say his health won't take it. 1253 01:41:45,250 --> 01:41:48,959 The hours he's working are daft. Our expectations were unrealistic. 1254 01:41:49,090 --> 01:41:53,402 Look, Don's a man who's been working all of his life in face creams and cosmetics. 1255 01:41:53,530 --> 01:41:56,920 With this oil, he's having the time of his life. You tell him. I won't. 1256 01:41:57,050 --> 01:41:59,325 All right. For his own sake, I'll have to. 1257 01:41:59,450 --> 01:42:03,888 Then you can call Mrs Odone and tell her that you've pulled the plug. 1258 01:42:06,491 --> 01:42:09,642 I'd best leave him be. -I think you're right. 1259 01:42:21,091 --> 01:42:23,047 Omouri! 1260 01:43:07,653 --> 01:43:10,804 Lorenzo... Omouri is here. 1261 01:44:14,816 --> 01:44:17,967 Morning. -Good morning, Mr Suddaby. 1262 01:44:18,096 --> 01:44:22,055 There's a bottle of pure erucic acid triglyceride on my bench. 1263 01:44:22,176 --> 01:44:26,055 Will you see that it gets to young Mr Odone as soon as possible, please? 1264 01:44:26,696 --> 01:44:28,652 I'm off home now. Bye-bye. 1265 01:44:29,576 --> 01:44:31,215 Goodbye, Mr Suddaby. 1266 01:44:34,937 --> 01:44:37,531 Well, we'd better get on with it. 1267 01:44:38,657 --> 01:44:40,613 September 1986 1268 01:44:45,857 --> 01:44:49,213 Four parts our old friend, the oleic. 1269 01:44:50,617 --> 01:44:52,573 And... 1270 01:44:53,137 --> 01:44:56,174 one part erucic. 1271 01:44:57,858 --> 01:45:01,407 And the journey begins, and like all good journeys,... 1272 01:45:01,538 --> 01:45:04,098 with food. 1273 01:45:06,538 --> 01:45:08,688 Where's the wretched nurse? 1274 01:45:08,818 --> 01:45:12,527 I'm gonna take my baseline myself if she doesn't get here soon. 1275 01:45:12,658 --> 01:45:16,287 A month is much too long. If we check my blood every week... 1276 01:45:16,418 --> 01:45:21,652 and I have a cardiogram, we should know enough to start Lorenzo sooner. 1277 01:45:21,779 --> 01:45:23,929 Oh, at last! 1278 01:45:32,019 --> 01:45:33,737 Hi. 1279 01:45:33,859 --> 01:45:35,577 How's the mother tiger? 1280 01:45:37,099 --> 01:45:40,887 Augusto didn't tell you? I'm here to be Lorenzo's rat. 1281 01:45:43,059 --> 01:45:45,619 That's a very kind offer, but I can't let you. 1282 01:45:45,739 --> 01:45:49,528 I'm a carrier, just like you. My blood levels are just as high as yours. 1283 01:45:49,660 --> 01:45:53,414 I've had my baseline taken... and I'm starving. 1284 01:45:54,980 --> 01:45:58,575 Oh, I have been wanting to meet Lorenzo's main man. 1285 01:45:59,780 --> 01:46:02,055 I am content to greet Aunt Deirdre. 1286 01:46:02,180 --> 01:46:04,694 Well, it's good to meet you too. 1287 01:46:04,820 --> 01:46:09,291 Now, now, Michaela. I want no argument. Michaela, you cannot test it. 1288 01:46:09,420 --> 01:46:13,414 Lorenzo needs you fit and well.p -So you would put Deirdre at risk... 1289 01:46:13,541 --> 01:46:17,819 without even discussing... -Hey! I backpacked all through India. 1290 01:46:17,941 --> 01:46:20,853 I must have eaten rapeseed oil up the wazoo. 1291 01:46:20,981 --> 01:46:24,337 Ah, I've been fasting all day. -All right, go ahead. Try it. 1292 01:46:24,461 --> 01:46:26,417 OK, here goes. 1293 01:46:30,101 --> 01:46:32,376 So... does it taste awful? 1294 01:46:33,221 --> 01:46:35,291 No? Good. -It's good. 1295 01:46:35,421 --> 01:46:37,731 Good. Eat, eat. 1296 01:46:42,222 --> 01:46:44,497 Your sister had no side effects? 1297 01:46:44,622 --> 01:46:46,375 None at all. If we can normalise the levels 1298 01:46:46,376 --> 01:46:48,900 of a carrier so quickly, who knows? 1299 01:46:49,022 --> 01:46:51,934 We'll start Lorenzo immediately. -Marvellous. 1300 01:46:52,062 --> 01:46:53,973 We're all terribly grateful. -No, no. 1301 01:46:54,102 --> 01:46:58,653 Not to mention Deedee, the family rat. 1302 01:46:58,782 --> 01:47:02,458 What dosage will you give the lad? -We don't have time to be conservative. 1303 01:47:02,583 --> 01:47:04,892 We've decided on eight grams. 1304 01:47:37,984 --> 01:47:39,940 September 27th 1986 1305 01:48:12,225 --> 01:48:13,863 Hello. -Mr Odone? 1306 01:48:13,985 --> 01:48:15,338 Odo-ne, yes. 1307 01:48:15,465 --> 01:48:18,856 Look, we have a problem with this blood sample. 1308 01:48:18,986 --> 01:48:21,819 You have a problem? What is the problem? 1309 01:48:21,946 --> 01:48:25,302 Could there have been a mistake in the labelling? 1310 01:48:25,426 --> 01:48:28,065 No. No mistake. Why? 1311 01:48:28,186 --> 01:48:33,738 Well, we ran the assay twice and the levels of C24 and C26 read normal. 1312 01:48:39,706 --> 01:48:41,662 They read normal? 1313 01:48:42,626 --> 01:48:45,585 Well, uh, I... 1314 01:48:46,787 --> 01:48:48,903 Do you have the sample in front of you? 1315 01:48:49,027 --> 01:48:50,585 Yes. 1316 01:48:50,707 --> 01:48:54,495 What is the name on the sample? -Lorenzo Michael Murphy Odone. 1317 01:48:54,627 --> 01:48:56,583 It's Odo-ne. 1318 01:48:57,307 --> 01:48:59,457 No, there's no mistake. 1319 01:49:00,427 --> 01:49:03,180 But thank you very much. -OK, bye. 1320 01:49:18,828 --> 01:49:22,787 December 8th 1986 Thirty-two Months After Diagnosis 1321 01:49:27,748 --> 01:49:30,023 What's going on? -His levels are normal. 1322 01:49:30,148 --> 01:49:32,708 Play! Play! -Oh, that's wonderful! 1323 01:49:36,029 --> 01:49:38,543 Now, drink it up, son. 1324 01:49:38,669 --> 01:49:40,864 Every last drop. Good. 1325 01:49:42,429 --> 01:49:46,581 Mom says this is the only bottle in the world. 1326 01:49:48,229 --> 01:49:51,027 Now that we have destroyed Lorenzo's blood fats,... 1327 01:49:51,149 --> 01:49:55,108 I'm sure that Mr Suddaby will make us plenty more, huh? 1328 01:49:55,949 --> 01:49:59,499 Mom says this is bootleg. 1329 01:50:01,070 --> 01:50:03,459 I know this is only a fraction of what it cost... 1330 01:50:03,590 --> 01:50:06,150 -No, no, no, Wendy. -You gotta take it. 1331 01:50:06,270 --> 01:50:09,421 No, we work on the barter system. 1332 01:50:09,550 --> 01:50:12,018 Our oil, your produce, huh? 1333 01:50:12,150 --> 01:50:15,381 There aren't that many potatoes in the world. 1334 01:50:15,510 --> 01:50:17,466 OK. Here you go. 1335 01:50:19,070 --> 01:50:20,788 So, when will you tell Nikolais? 1336 01:50:20,910 --> 01:50:24,586 Well, we told him and the other doctors and we sent all the figures. 1337 01:50:24,711 --> 01:50:28,784 What did they have to say? -They deliberate. They want more study. 1338 01:50:28,911 --> 01:50:32,108 Wendy, that's enough. -So the other kids have to wait? 1339 01:50:32,231 --> 01:50:34,347 We know what to do about that, don't we? 1340 01:50:34,471 --> 01:50:37,543 The doctors had a very hard time swallowing the first oil. 1341 01:50:37,671 --> 01:50:40,981 They want to see how it goes with Lorenzo on the second. 1342 01:50:41,111 --> 01:50:43,386 But we don't have time, do we? -No. 1343 01:50:43,511 --> 01:50:46,662 So we leave science to its own concerns, huh? 1344 01:50:48,311 --> 01:50:50,667 Merry Christmas. -Goodbye, Jake. 1345 01:51:24,153 --> 01:51:26,792 What happened to the suction machine? 1346 01:51:26,913 --> 01:51:30,701 There's no need, Michaela. Not for four hours. 1347 01:51:30,833 --> 01:51:32,664 I turned the machine off. 1348 01:51:35,353 --> 01:51:38,026 All last night he made to swallow for himself. 1349 01:51:39,073 --> 01:51:41,713 Augusto! Augusto! 1350 01:51:46,434 --> 01:51:48,390 February 1987 1351 01:51:51,594 --> 01:51:54,267 We hope to make an announcement quite soon... 1352 01:51:54,394 --> 01:51:58,069 about a new development in our diet therapy. 1353 01:51:58,194 --> 01:52:01,186 It's expensive but, with the help of the government... 1354 01:52:01,314 --> 01:52:03,874 and of this wonderful foundation,... 1355 01:52:03,994 --> 01:52:08,352 we are going to start a trial before the end of the year. 1356 01:52:09,075 --> 01:52:11,635 Six Months Later 1357 01:52:17,075 --> 01:52:20,431 I can hear from that that you wish us Godspeed. 1358 01:52:31,316 --> 01:52:32,988 Excuse me, Doctor! 1359 01:52:33,116 --> 01:52:36,347 Are you referring to the oil the Odones have invented for Lorenzo? 1360 01:52:36,476 --> 01:52:39,388 We'll take questions later. -No, it's a good question. 1361 01:52:39,516 --> 01:52:43,748 I should have mentioned it perhaps but... The Odones have been extremely active... 1362 01:52:43,876 --> 01:52:45,787 and we are in their debt. 1363 01:52:45,916 --> 01:52:48,476 Thanks to them, we are preparing a protocol... 1364 01:52:48,596 --> 01:52:51,668 for review by the human-studies committee. 1365 01:52:51,796 --> 01:52:54,913 If then we can persuade the government to fund us,... 1366 01:52:55,036 --> 01:53:00,509 then we shall know if this oil is of more than temporary therapeutic value. 1367 01:53:00,637 --> 01:53:03,788 But it works! Lorenzo's blood levels are down to normal. 1368 01:53:03,917 --> 01:53:08,115 It's precisely for that reason that we are conducting this trial. 1369 01:53:08,237 --> 01:53:10,467 You don't expect me to endorse a therapy... 1370 01:53:10,597 --> 01:53:13,669 just on the basis of one hopeful observation? 1371 01:53:13,797 --> 01:53:16,914 There's two! My boy's been takin' the oil for six months. 1372 01:53:17,037 --> 01:53:20,154 Yes, Ellard, and his blood levels are down to normal. He's fine. 1373 01:53:20,277 --> 01:53:22,109 You are playing with people's hopes. 1374 01:53:22,238 --> 01:53:27,232 Where do these Odones get off, thinking they know more than the doctors? 1375 01:53:27,358 --> 01:53:30,634 Where did you get this oil? -The Odones. They get it from England. 1376 01:53:30,758 --> 01:53:32,645 They don't have approval from the FDA. 1377 01:53:32,646 --> 01:53:34,831 It's bootleg. Give the doctors a chance... 1378 01:53:34,958 --> 01:53:37,631 Come on, Ellard! It's a mixture of two cooking oils. 1379 01:53:37,758 --> 01:53:40,074 Two cooking oils? What's the dosage, please? 1380 01:53:40,075 --> 01:53:41,876 What are the side effects of this? 1381 01:53:41,998 --> 01:53:44,910 How would we pay for it? -There must be a formal protocol... 1382 01:53:45,038 --> 01:53:49,510 before we can raise funds. I understand it will cost over $1,000 a litre. 1383 01:53:49,639 --> 01:53:55,350 And no insurance company or government will support you without the approval. 1384 01:53:55,479 --> 01:53:58,437 And the only way to get it is through thorough testing. 1385 01:53:58,559 --> 01:54:02,029 That's what they told AIDS people about AZT, but they fought and got it. 1386 01:54:02,159 --> 01:54:05,674 Because they were dying. They didn't have time to wait... 1387 01:54:05,799 --> 01:54:08,950 We padded our walls yesterday! I want that oil! 1388 01:54:16,720 --> 01:54:18,836 May 1988 Lorenzo's Tenth Birthday 1389 01:54:18,960 --> 01:54:22,509 There, my darling. That's a sweet boy. 1390 01:54:24,360 --> 01:54:26,316 What a big, strong boy. 1391 01:54:27,160 --> 01:54:29,515 Yes, my darling. Yes. 1392 01:55:01,001 --> 01:55:02,560 You see, Michaela,... 1393 01:55:02,682 --> 01:55:06,880 it's as though he is trapped down in some dark cave. 1394 01:55:08,322 --> 01:55:13,396 Because he's lost so much myelin, he can't find his way out. 1395 01:55:13,522 --> 01:55:17,151 Now, we know his simple functions are intact. 1396 01:55:17,282 --> 01:55:20,877 He breathes, he swallows, his heart beats. 1397 01:55:21,602 --> 01:55:26,357 And from the outside world, he receives sensation. 1398 01:55:26,482 --> 01:55:28,439 A touch,... 1399 01:55:30,003 --> 01:55:31,959 pain, cold. 1400 01:55:32,603 --> 01:55:35,800 And here are the primal feelings. 1401 01:55:35,923 --> 01:55:38,960 Fear, hunger, desire. 1402 01:55:40,483 --> 01:55:45,921 While up here in the neocortex, the higher brain, locked here,... 1403 01:55:46,043 --> 01:55:50,161 are his reasoning, imagination, memory. 1404 01:55:51,283 --> 01:55:54,037 The things that make us each ourselves. 1405 01:55:59,004 --> 01:56:00,960 So how does he reach us? 1406 01:56:03,884 --> 01:56:07,035 When a simple swallow is such a huge task? 1407 01:56:10,484 --> 01:56:12,440 To find... 1408 01:56:13,044 --> 01:56:16,878 To find the way, the path from his mind... 1409 01:56:18,645 --> 01:56:20,601 to the outside world... 1410 01:56:22,605 --> 01:56:25,961 is like willing himself through a brick wall. 1411 01:56:28,165 --> 01:56:30,121 So he waits, huh? 1412 01:56:35,085 --> 01:56:37,041 He waits. 1413 01:56:39,245 --> 01:56:41,201 Michaela... 1414 01:56:46,366 --> 01:56:48,322 Do you ever think... 1415 01:56:51,006 --> 01:56:52,962 that... 1416 01:56:54,446 --> 01:56:57,404 maybe all this struggle,... 1417 01:56:59,486 --> 01:57:03,035 it may have been for somebody else's kid? 1418 01:57:21,167 --> 01:57:23,123 Yes. 1419 01:57:52,408 --> 01:57:55,161 But I promised... I promised him... 1420 01:57:55,888 --> 01:57:58,244 his world would never be silent. 1421 01:58:00,129 --> 01:58:02,085 He would never be alone. 1422 01:58:03,569 --> 01:58:05,321 Yes. 1423 01:58:05,889 --> 01:58:07,845 Two Years Later 1424 01:58:08,049 --> 01:58:10,768 "One morning, a little rabbit sat on a bank." 1425 01:58:10,889 --> 01:58:15,041 "He pricked his ears and listened to the trit-trot, trit-trot of a pony." 1426 01:58:15,169 --> 01:58:18,639 "A gig was coming along the road. It was driven by Mr McGregor." 1427 01:58:18,769 --> 01:58:22,125 "And beside him sat Mrs McGregor in her best bonnet." 1428 01:58:22,249 --> 01:58:25,845 "As soon as they had passed, little Benjamin Bunny slid down into the road... 1429 01:58:25,970 --> 01:58:29,883 and set off with a hop, skip and a jump to call upon his relations,... 1430 01:58:30,010 --> 01:58:33,559 who lived in the woods at the back of Mr McGregor's garden." 1431 01:58:33,690 --> 01:58:38,127 "That wood was full of rabbit holes, and in the neatest, sandiest hole of all... 1432 01:58:38,250 --> 01:58:43,165 lived Benjamin's aunt and his cousins, Flopsy, Mopsy, Cottontail and Peter." 1433 01:58:43,290 --> 01:58:46,487 "Old Mrs Rabbit was a widow. She" 1434 01:58:46,610 --> 01:58:50,047 "earned her living by knitting rabbit-wool mittens and muffeties." 1435 01:58:50,171 --> 01:58:52,127 "I once bought a pair" 1436 01:58:53,571 --> 01:58:56,529 What's the matter, darling? You don't like the story? 1437 01:59:03,851 --> 01:59:05,603 Lorenzo... 1438 01:59:07,531 --> 01:59:09,169 You don't like the story? 1439 01:59:11,891 --> 01:59:13,769 He does that a lot lately. 1440 01:59:13,892 --> 01:59:16,042 When? -Mainly at story time. 1441 01:59:17,212 --> 01:59:19,168 Sweetheart... 1442 01:59:19,652 --> 01:59:21,608 Listen carefully to Mama. 1443 01:59:23,572 --> 01:59:26,211 Is your middle name Patrick? 1444 01:59:30,012 --> 01:59:33,084 No... Is it Peter? 1445 01:59:36,172 --> 01:59:38,208 No, Mommy. 1446 01:59:38,332 --> 01:59:41,052 Is it Michael? Michael Murphy? 1447 01:59:44,053 --> 01:59:45,645 Yes! Yes! 1448 01:59:45,773 --> 01:59:47,729 Only you don't know how to say that. 1449 01:59:47,853 --> 01:59:50,208 Will you teach Mommy how to say no? 1450 01:59:50,333 --> 01:59:53,484 When you close your eyes, does that mean no? 1451 01:59:53,613 --> 01:59:56,685 Oh, what an idiot! That was a yes question. 1452 01:59:56,813 --> 02:00:01,682 All right. You don't want to hear any more Benjamin Bunny, do you? 1453 02:00:04,294 --> 02:00:07,650 That's an emphatic reply! Very well, young man. 1454 02:00:08,694 --> 02:00:13,688 No more Benjamin Bunny. How could Mommy have been so thoughtless? 1455 02:00:13,814 --> 02:00:18,285 We're going to take all of these baby books to the children's hospital. 1456 02:00:18,414 --> 02:00:21,804 It's time for the big stuff. Something heroic. 1457 02:00:21,934 --> 02:00:24,812 There you go. You gotta tell us what you want. 1458 02:00:24,934 --> 02:00:27,971 The Once and Future King by TH White. 1459 02:00:30,615 --> 02:00:35,006 "The boy slept well in the woodland nest, where he had laid himself down." 1460 02:00:35,135 --> 02:00:38,093 "At first, he only dipped below the surface of sleep... 1461 02:00:38,215 --> 02:00:41,252 and skimmed along like a salmon in shallow water,... 1462 02:00:41,375 --> 02:00:45,732 so close to the surface that he fancied himself in air." 1463 02:00:46,615 --> 02:00:49,891 "He thought himself awake, when he was already asleep." 1464 02:00:50,015 --> 02:00:51,687 "He saw the stars above his face,... 1465 02:00:51,815 --> 02:00:54,728 whirling on their silent and sleepless axis,... 1466 02:00:54,856 --> 02:00:58,246 and the leaves of the trees rustling against them." 1467 02:00:58,376 --> 02:01:01,448 "And he heard small changes in the grass." 1468 02:01:01,576 --> 02:01:05,888 "These little noises of footsteps and soft-fringed wing beats... 1469 02:01:06,016 --> 02:01:08,655 and stealthy bellies drawn over the grass blades." 1470 02:01:08,776 --> 02:01:14,134 "A rattling against the bracken at first frightened him, but interested him." 1471 02:01:19,457 --> 02:01:21,095 OK. Is it your thumb? 1472 02:01:23,777 --> 02:01:25,733 Is it your index finger? 1473 02:01:28,257 --> 02:01:30,213 Your middle finger? 1474 02:01:31,857 --> 02:01:34,087 Your little finger? 1475 02:01:34,217 --> 02:01:38,495 It's your little finger. You think you can move your little finger. 1476 02:01:38,617 --> 02:01:42,246 OK. Tell your brain to tell your arm... 1477 02:01:42,377 --> 02:01:45,734 to tell your hand to move your little finger. 1478 02:01:48,618 --> 02:01:51,576 Come on, sweetheart. Tell your brain to tell your arm... 1479 02:01:51,698 --> 02:01:54,974 to tell your hand to move your little finger. 1480 02:01:55,938 --> 02:01:58,498 Come on, my friend. What a wonderful thing. A "yes". 1481 02:01:58,618 --> 02:02:01,337 And then there'll be a "could be" and a "perhaps"... 1482 02:02:01,458 --> 02:02:04,848 and maybe even a "shut up, Mommy", but now we just have to get to "yes". 1483 02:02:04,978 --> 02:02:07,936 So tell your brain to tell your arm... 1484 02:02:08,058 --> 02:02:11,210 to tell your hand to move your little finger. 1485 02:02:14,339 --> 02:02:17,854 Come on, my love. Tell your brain to tell your hand... 1486 02:02:18,259 --> 02:02:20,215 to move your little finger. 1487 02:02:23,019 --> 02:02:26,136 Come on, Lorenzo. -You can do it, my friend. 1488 02:02:26,259 --> 02:02:28,215 You can do it. 1489 02:02:29,539 --> 02:02:31,495 Come on, Lorenzo. 1490 02:02:46,860 --> 02:02:50,933 UNIVERSITY OF WISCONSIN School of Veterinary Medicine 1491 02:02:51,060 --> 02:02:54,336 And they are born without myelin, correct? 1492 02:02:54,460 --> 02:02:58,419 The only naturally dismyelinated higher mammals in existence. 1493 02:02:58,540 --> 02:03:00,816 And this is passed from mother to son? 1494 02:03:00,941 --> 02:03:02,852 Yes. 1495 02:03:02,981 --> 02:03:06,132 Their mother is from Edinburgh. That's Jasmine. 1496 02:03:06,261 --> 02:03:08,616 She doesn't shake, but her male pups do. 1497 02:03:09,141 --> 02:03:13,453 You think you can stop them shaking? -Well, we hope so. 1498 02:03:13,581 --> 02:03:17,859 By implanting nerve cells, we expect to see the growth of new myelin. 1499 02:03:17,981 --> 02:03:21,257 We've been partially remyelinating rats and mice for ten years,... 1500 02:03:21,381 --> 02:03:23,531 and it's repeatable. 1501 02:03:24,501 --> 02:03:29,701 But if we could fund this work, it could be the first in higher animals. 1502 02:03:29,822 --> 02:03:32,620 And then in human beings, huh? 1503 02:03:32,742 --> 02:03:34,698 Well, in time, yes. 1504 02:03:35,342 --> 02:03:38,812 Dr Duncan, if I help you raise these funds... 1505 02:03:38,942 --> 02:03:42,139 and if we can get the researchers together to collaborate,... 1506 02:03:42,262 --> 02:03:46,460 I think we can achieve very much in a very short time. 1507 02:03:46,582 --> 02:03:50,257 Augusto, we scientists are a very competitive lot. 1508 02:03:50,382 --> 02:03:55,662 Such a collaboration is a lovely idea, but sadly that is not how science works. 1509 02:03:55,783 --> 02:04:00,493 That's not necessarily so, because remember the Manhattan Project? 1510 02:04:00,623 --> 02:04:04,411 28 months. It took them 28 months. 1511 02:04:04,543 --> 02:04:08,695 Now, if scientists can come together to build the atomic bomb,... 1512 02:04:08,823 --> 02:04:13,533 surely they come together to remyelinate some puppy dogs? 1513 02:04:24,664 --> 02:04:27,132 Papa called from Italy, darling. 1514 02:04:27,264 --> 02:04:30,939 He's missing his Lorenzacchio very, very much. 1515 02:04:31,064 --> 02:04:34,977 But he wants me to tell you he's making a big dinner tonight,... 1516 02:04:35,104 --> 02:04:39,063 a banquet of brain food for the cleverest doctors in the world... 1517 02:04:39,184 --> 02:04:43,178 who've gathered together to put the myelin back in the shaking puppy dogs. 1518 02:04:43,305 --> 02:04:45,773 And if they can achieve that,... 1519 02:04:45,905 --> 02:04:50,535 someday there might be a way to help all the people who've lost their myelin. 1520 02:04:50,665 --> 02:04:54,578 Not only the boys with ALD, but the people with multiple sclerosis... 1521 02:04:54,705 --> 02:04:57,265 and many other diseases, Lorenzo. 1522 02:04:58,065 --> 02:05:02,775 And then think, my brave boy, if they can ever give you back your myelin,... 1523 02:05:02,905 --> 02:05:08,856 you'll be able to tell your brain to tell your toes, your fingers, your anything, 1524 02:05:08,986 --> 02:05:11,784 to do what you want them to do. -... what I want them to do. 1525 02:05:11,906 --> 02:05:14,136 And then, one day,... 1526 02:05:14,906 --> 02:05:16,976 I'll hear my voice... 1527 02:05:17,106 --> 02:05:21,657 and all these words I'm thinking will get outside my head. 1528 02:05:26,226 --> 02:05:29,696 This film was completed at the end of 1992 and so far... 1529 02:05:29,826 --> 02:05:34,025 Doctors all over the world have begun to prescribe Lorenzo's Oil. 1530 02:05:34,147 --> 02:05:38,504 If a diagnosis is made early enough the treatment stops the disease. 1531 02:05:38,627 --> 02:05:43,064 So there is now a growing army of boys kept free from the ravages of ALD. 1532 02:05:43,187 --> 02:05:48,307 In recognition of this, Augusto Odone received an honorary medical degree. 1533 02:05:48,427 --> 02:05:53,455 He and Michaela continue to raise funds and drive the scientific task force... 1534 02:05:53,587 --> 02:05:55,782 known as "The Myelin Project". 1535 02:05:55,907 --> 02:05:59,457 The Shaking Pups are successfully growing new myelin. 1536 02:05:59,588 --> 02:06:03,058 This means that human trials will begin within a year. 1537 02:06:03,188 --> 02:06:07,545 There are many waiting to receive the first brain cell transplants. 1538 02:06:07,668 --> 02:06:10,546 Among them is Lorenzo Michael Murphy Odone. 1539 02:06:11,668 --> 02:06:14,136 Meanwhile... Lorenzo is 14 years old. 1540 02:06:14,268 --> 02:06:17,260 He is now able to move his head from side to side. 1541 02:06:17,388 --> 02:06:21,666 He has recovered his eyesight and begun to vocalise simple sounds. 1542 02:06:21,788 --> 02:06:25,179 He is learning to communicate by means of a computer. 1543 02:06:25,309 --> 02:06:28,062 And so he waits, for what will come next... 1544 02:06:32,349 --> 02:06:34,499 Oh! Now it broke! 1545 02:06:38,589 --> 02:06:41,149 This is Charles and this is Harry... 1546 02:06:41,269 --> 02:06:44,147 and they've both been on Lorenzo's Oil for two years. 1547 02:06:44,269 --> 02:06:47,546 My name is Michael Benton and I'm twelve and a half years old. 1548 02:06:47,670 --> 02:06:50,980 I've been taking Lorenzo's Oil for four and a half years. 1549 02:06:51,110 --> 02:06:56,742 I was diagnosed with ALD when I was 13 years old. I'm taking Lorenzo's Oil... 1550 02:06:56,870 --> 02:06:59,668 I've been taking Lorenzo's Oil for three years. 1551 02:06:59,790 --> 02:07:04,420 Some of the activities I'm involved in are baseball, basketball... 1552 02:07:09,790 --> 02:07:24,420 ãÍãæÏ!!!!!!!!!!